Dishonored 2 Safe Combinations

Mission 3: The Good Doctor

Name: Vasko’s Monitor Safe

Safe location: On the second floor of the Addermire Institute. Once you exit the elevator, go left.
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Go through the lab, and enter Vasco’s office on the other side. You’ll find the safe by the desk.
Combination location: After you talk to Hypatia, look around. You’ll find a badly injured man on a stretcher. Talk to him, and he’ll tell you the combination.
Rewards: Vasco’s journal, Addermire solution

Click here to watch the video walkthrough for Mission 3: Vasko’s Monitor Safe Combination

Name: Steel Monitor Safe

Safe location: Go to the lobby of the Addermire Institute. Walk towards the consultation area on the right. Teleport onto the balcony and head left. You’ll find the safe in the large office.
Combination location: On a desk on the other side of the office.
Rewards: Combat sleep dart blueprint, Copper wire, Silver ingot
Thanks to Jacob for the additional info.
Click here to watch the video walkthrough for Mission 3: Near the main entrance Safe Combination

Mission 4: The Clockwork Mansion Safe Code Location

Name: Lower Aventa District safe

Safe location: As you start the mission you’ll exit the sewers. To your left will be a large building with a map board. Left of the map board is an alleyway. Go down it until you reach a couple of people and enter the apartment building behind them. Up on the first floor you’ll find an office room with the safe (there’s a work desk and a chair inside as well.
Combination location: There is a blackboard on the wall across the entrance into the office with the safe. Hidden behind a bottle and some glasses are two numbers. Put those two numbers into the safe lock and rotate the third wheel until you get the combination and open the safe.
Rewards: Gathering of the Regenters book, Lucky Sphalerite, 2xSilver ingot

Click here to watch the video walkthrough for Mission 4: The Clockwork Mansion (Lower District)

Mission 5: The Royal Conservatory

Name: Winslow Safe

Safe location: In the condemned building across the road from the conservatory’s main entrance. Climb the plateau with the bar and jump across the gap onto the balcony. As you enter, turn left and go into the office. You’ll see the safe there, by the wall. Expect a lot of bloodflies, and an infected enemy.
Combination location: Go to the black market vendor in the area, and simply buy the combination from him.
Rewards: Pistol, Pistol ammo, 5x Silver ingot, Silver dust

Click here to watch the video walkthrough for Mission 5: The Royal Conservatory Safe combination

Mission 7: A Crack In The Slab

Name: Steel Monitor Safe

Safe location: When you reach the round foyer with the tree in the middle, jump to the past and turn left. Go past the steel door, then turn right. Go under the desk, all the way to the wall. Jump to the present, and you’ll be on the other side. Transition to the past, and you’ll see the safe in front of you.
Combination location: While you’re in the room with the safe, in the past, pick up the wolfdog corpse. Throw it into the furnace and incinerate it. When you return to the present, you’ll see the safe door on the floor, without the bloodfly nest blocking it. Read the combination off of it.
Rewards: Bonecharm, Silver ingot, Coins, Konos star tables

Click here to watch the video walkthrough for Mission 7: A Crack in The Slab

Mission 8: The Grand Palace

Name: Steel Monitor Safe

Safe location: When you’re in the courtyard with the giant tree, turn towards the big wooden wall. Enter the building next to it, on the left. Climb the stairs and use Shadow Walk/Possession to get into the apartment. The safe will be in the large room.
Combination location: When you face the safe, turn around and go into the tiny workshop. Look to your right – there will be a black and white photo of a man with a safe. Look closely at the safe, and you’ll see the combination.
Rewards: Pistol, Pistol Bullets, Silver Ingot, Gold Ingot

Click here to watch the video walkthrough for Mission 8: The Grand Palace

Name: First Captain’s Safe

Safe location: In the First Captain’s Office. Enter the throne room from the terrace, and go into the foyer with the round bench. Take the left hallway and enter the office. The safe is behind the desk.
Combination location: You’ll find it in the Duke’s office – it’s the room direclty under his suite. It’s on the desk to the left of the Duke’s desk, from where you enter.
Rewards: Rune

Click here to watch the video walkthrough for First Captain’s Safe Combination

If you happen upon any safes we don’t have on the list, feel free to share both their locations and where to find the combinations that’ll open them.

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Ketchua has been writing about games for far too long. As Señor Editor, he produces words (and stuff) for Gosunoob. There are a lot of words (and stuff) there, so he's terribly busy. Especially if you need something.