The Secret of Cabot House Fallout 4 Quest

The Secret of Cabot House is the last in a small chain of Fallout 4 side quests that start when you talk to a Ghoul named Edward Deegan. It is an important side quest chain because it grants you access to Parsons State Insane Asylum, where you’ll find the Charisma Bobblehead, Massachusetts Surgical Journal and you can also receive a unique weapon reward – Lorenzo’s Artifact Gun or Zeta Gun. At the end of this quest you will have a choice to make and that is why we’ve written this guide; to tell you the consequences of your choice (in case you are wondering). This means that there are heavy spoilers ahead. Quests you need to finish to get this one are Special Delivery and Emogene Takes a Lover, but we’ll discuss those in another guide.

Meet Jack outside Parsons State Insane Asylum

The first few steps of this quest take you to Parsons State Insane Asylum. Jack finally unlocks the building and you should follow him around as he makes his way toward his office. You will have to fight raiders along the way. At one point you will reach a chained room Jack opens and this is Jack’s Office. On his desk, next to the computer terminal is the Charisma Bobblehead. Keep following Jack to the main asylum and fight the Raider threat along the way. You’ll reach the laboratory where Lorenzo Cabot is being held along with some Raiders trying to get inside his cell. Raider mini boss called Lefty is the one you will have to be careful about, but he stands between you and Lorenzo so remove that obstacle.

Kill or free Lorenzo Cabot

kill or free lorenzo cabotYou now have two options. One is to flip the four switches around the room and kill Lorenzo, or set him free. Each choice has different rewards outcome (not to mention the morality of the situation you’ll have to live with). In either case don’t forget to pick up Massachusetts Surgical Journal in the room Lorenzo is being held in. It gives “Permanently inflict +2% limb damage.” perk (per issue of the magazine found).

Kill Lorenzo

Just flip all the switches and Lorenzo is no more. Going inside his cell you can find some nice scrap-able junk. Jack Cabot will be pleased and tell you to meet him at the Cabot House in about a week. You also get a nice reward of caps (I got over 500 when I handed it in). You can either play until a week passes in-game or sleep at a bed to pass the time. You’ll get an update of the quest saying Talk to Jack Cabot about the artifact. When you are there you will find out that Jack created a weapon that uses the artifact’s psychic powers to knock enemies about. If you were not rude to Jack over the course of his side quests he will reward you with Lorenzo’s Artifact Gun. Screenshot bellow shows the stats on the weapon, which uses rare Gamma Round ammunition. Weapon is also rather special because it applies knockback wave force to your enemies. You will have enemies flying through space in no time.

UPDATE: Player Egg rage from our Facebook page gave us the following tip: After you wait for a week to get the artifact gun you can go back to Jack Cabot’s house and find the Zeta gun on a table in his lab, on the second floor. This way you get both rewards. Cheers Egg rage.

lorenzos artifact gun fallout 4

Free Lorenzo

If you decide that Jack is just leeching off of his old man and think that Lorenzo is not crazy, you can decide not to kill him. Jack will run back to the Cabot House and Lorenzo will follow after him. Back at the Cabot House you have one more chance to change your mind and side with the family. Jack will start talking to you and you can choose to say that he is wrong, which will lead to you killing the family, or you can choose to say that you were wrong, which will lead to a fight with Lorenzo.

If you side with Lorenzo, killing the rest of the family is easy and you can loot a Zeta Gun weapon from Jack Cabot. It is a unique weapon that uses Gamma ammo and I did not find it particularly powerful. You will also get a vial of Lorenzo’s blood called Mysterious Serum. This removes rads, provides +5 STR and 50 damage resist. Once you use it you can come back to Lorenzo and pick up another vial, so you have an endless supply of antirads. You will also be able to have a random encounter with Lorenzo later in the game where he is investigating dead Ghouls. Your companions will largely dislike you killing the Cabot family, so have that in mind.

If you, however, change your mind and decide to kill Lorenzo after all, you are in for a tough fight. He has a lot HP and you should be careful of his psychic AOE attack. Make sure you inject the serum before fighting him – it will make you hurt him more in combat (thanks Alienfacepalm for the hint). In the end you will receive Lorenzo’s Artifact Gun and bottlecaps from Jack.

Author Serge profile picture
Having games be part of his life since Commodore 64 it was only natural that Serge co-founded With every new game he travels from being the Noob to being Gosu. Whether he does coding or editorial work on the website he is still amazed by the fact that gaming is what he does for living.

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  1. T

    You can loot that zeta gun before you go out side to walk and talk with Jack, everything in the house turns from steal, to take, you can then go up stairs and just take the zeta gun, it doesn’t even say it’s stealing, you can also scavenge all the useful things in the house, about 20 doors in the place, almost seemed never ending

    1. D

      I stole the Zeta Gun, then sided with Lorenzo and looted a second one. Along with all of the rest of the loot in the house. Plus the 5 str vials. No reason at all to side with Jack.

      1. F
        Fallout 4

        Something you can do is if you side with the Cabot people is bring Lorenzo to their house. Then, you kill him and go to the upstairs you’ll find the Zeta Gun apologize to the Cabots then he’ll tell you to come in a week or so, then you’ll get Lorenzo’s gun when it tells you to go back to the Cabot guy then pickpocket him to get more gamma ammo and get another Zeta Gun. Also, when you go to the upstairs there will be gamma ammo next to the gun.

    2. so i see that this mysterious serum reverses your age and you can live forever but that doesnt really matter for you cuz you cant get old any way so i say we just give it to sean

      1. .

        the serum gets rid of an insane amount of rads from what i saw

  2. D

    Uhhh… and WHERE do we get this quest? im at the asylum they were a tons of mercenary who attacked me so i killed them . but NO ghoul, door still closed

    1. S

      Find Cabot House and speak on the intercom to convince the Cabot family to let you in.
      Then you will get 2 missions leading up to this one, on completion, go back to the Cabot House and they will be arguing and you get the mission once they stop arguing. Cabot House is just to the East of Old North Church where the Railroad are.

    2. P

      I started the chain of quests in Goodneighbor by talking to the ghoul there named Edward Deegan.

    3. J

      To obtain the quest you can talk to Edward the ghoul in Bunker Hill, or find the Cabot House and speak at the intercom.

      1. L

        Or you can go to diamond city and go to the Dig out bar and talk to the bartender about the man on the radio and keep following that until you help the scarred radioman fight in the bar, and the ghoul guy comes in saying that he can use a man that can handle himself, and boom there you go

    4. D

      You need to speak to the ghoul, Edward, at bunker Hill. He sends you out to speak to his boss, Jack, whom is not too far from bunker Hill.

      You get a few quests associated with Jack, so it’s worth the experience and loot.


  3. J

    Loot Zeta gun from Cabot House, kill Lorenzo and you have both guns, easy choice really…

  4. R

    i suppose to talk to jack cabot for my reward its been a week it says meet him at the asylum and hes not there…??

  5. W

    The Zeta gun and the unique artifact gun are two different things. I believe you can only get the unique artifact gun with the knockback effect if you kill Lorenzo.

    You can loot 5 or so serum by the time you kill lorenzo in the the chamber. Are there really going to be more than 5 times in the game where you need to be immune to radiation for more than 6 gameplay hours?

  6. A

    If you free Lorenzo but decide to kill him at Cabot House, injecting the “mysterious syrum” will greatly increase any damage you do to Lorenzo. It basically turns him into a normal enemy.

    1. M

      Need advice on this.. I accidentally freed Lorenzo, but decided to kill him with Jack. All I recieve do from Jack was 499 bottle caps. Didn’t recieve Lorenzo’s Artifact Gun from him. I’ve even waited a week + by sitting and no dice. Can someone confirm that you can actually get the gun this way. Or did I screw up royally?

  7. W

    A line from this walkthrough:

    “If you were not rude to Jack over the course of his side quests he will reward you with Lorenzo’s Artifact Gun”

    I think you might have chosen the wrong dialog option somewhere along the line.

    Another possibility is that if you must shoot at Jack at some point during the mission to fix the bug where he gets stuck in the injured sitting position, make sure you remain hidden while you do it.

  8. J

    Don’t forget the multiple Syrums on Lefty, as well as the 3 Syrums on the surgical trays in the basement (outside Lorenzo’s cell) near the microscopes.

  9. A

    How could you turn down un-aging life? If you want to push someone off, fire a rocket launcher or fat boy at them 😉

    +5 STR and 50% damage resistance is amazing. Given the lasts for 6 hours at a time, and you can just go get more, you should refill after every sleep and pop a new one. I think it actually is constantly removing RADS too. Lorenzo is super nice to you after you save him and give you an endless supply for Mysterious Serum, way way better than a knock back and it’s just the right thing to do.

    You can convince their bodyguard to join you, in which case he’ll help kill the other Cabbots when Lorenzo shows up.

  10. M
    Malus Mortum Diem

    There is also 1 vial at the front door to the building near the hand of the first raider.

  11. M
    Malus Mortum Diem

    This may have been said. BUT when you complete the quest keep coming back to the Cannot house. It will respawn with ALL the items (Fat Man, ammo, Zat Gun, Mini Nuke, weapons and all the Junk.)

  12. M
    michele lerouge

    slightly different experience on this one. without realizing what button I was pushing, I freed Lorenzo. Met back at Cabot House, Jack was at the front door we went in together. I am traveling with Curie. Turns out Curie had the Zeta gun on her after leaving the asylum (I found it with her as I was dumping loot over to her to carry). Then I ended up siding with the family and fighting/killing Lorenzo. He wasn’t too bad to kill – a bunch of different grenades did it. Jack gave me caps and I looted rest of house.

  13. B
    Butts McGee

    I can’t find Jack Cabot. I completed the quests and asked for the reward and waited a week, got the alert saying to go talk to Jack Cabot about the artifact but he doesn’t seem to be in Cabot House? Li’l help.

  14. S

    He’s at the institute still.

  15. G

    GUYS, when I do the mission, edward deegan doesn’t span inside the hospital, so quest is blocked because doctor seems to talk with nobody (near the elevator) and he is always busy.. Does anybody know how to fix this?

  16. G

    After couple of days and different quests done I cannot find lorenzo to get more serum, can someone help?

  17. B

    Go back to Cabot house. He should be there. Talk to him. He will give you more serum provided you don’t sell or give it away. He will only give you serum if you are out (he’ll tell you that).

  18. T

    I am at the point in this mission where my objective is “Talk to Jack Cabot about the artifact.” Ive waited two weeks. Im now at his house and the quest target is hovering above his dining room table. Nothing is there. Before we went to the asylum i stole the zheta gun. At the asylum i sided with lorenzo, then with jack once we got back to his house. My problem is I have no idea how to successfully complete this mission since the objective marker is hovering above nothing. I cant get jack to do anything besides the basic “hellos” Really frustrating.

    1. S

      I’m having the same problem did u find a way of sorting it thx in advance

  19. J
    John Rydings

    Hi Toe-Knee, did you solve this problem, I am suffering the same thing now grrrr

  20. J

    BEFORE you go outside to meet Jack, YOU NEED to hack his personal terminal and read EVERYTHING. Nothing is as it seems. It’s across from the Zeta Gun on the second floor. At this time you can look everything without it being considered stealing.

  21. O
    Owen Ross

    What if i chose it kill Jack Cabot and his family? Is there a way to still get the artifact mod?

  22. F

    Will Cait dislike if you open the door after killing lorenzo? I know she likes killing him and siding with Jack but can I open the door or will she hate/dislike that?

  23. M

    The first time you go to Cabot house if you get in through the intercom you can actually steal the zeta gun which is on the table on the lab upstairs, I myself managed to steal it 3 times as every time I came back it was there.

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